Enhanced Tumor Diagnostics via Cyber-Physical Workflow: Integrating Morphology, Morphometry, and Genomic MultimodalData Analysis and Visualization in Digital Pathology
Kucarov, Marianna Dimitrova and Szakállas, Niklolett and Molnár, Béla and Kozlovszky, Miklós (2025) Enhanced Tumor Diagnostics via Cyber-Physical Workflow: Integrating Morphology, Morphometry, and Genomic MultimodalData Analysis and Visualization in Digital Pathology. SENSORS, 25 (14). ISSN 1424-8220 10.3390/s25144465
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Abstract
The rapid advancement of genomic technologies has significantly transformed biomedical research and clinical applications, particularly in oncology. Identifying patient-specific genetic mutations has become a crucial tool for early cancer detection and personalized treatment strategies. Detecting tumors at the earliest possible stage provides critical insights beyond traditional tissue analysis. This paper presents a novel cyber-physical system that combines high-resolution tissue scanning, laser microdissection, next-generation sequencing, and genomic analysis to offer a comprehensive solution for early cancer detection. We describe the methodologies for scanning tissue samples, image processing of the morphology of single cells, quantifying morphometric parameters, and generating and analyzing real-time genomic metadata. Additionally, the intelligent system integrates data from open-access genomic databases for gene-specific molecular pathways and drug targets. The developed platform also includes powerful visualization tools, such as colon-specific gene filtering and heatmap generation, to provide detailed insights into genomic heterogeneity and tumor foci. The integration and visualization of multimodal single-cell genomic metadata alongside tissue morphology and morphometry offer a promising approach to precision oncology.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány |
| Divisions: | Laboratory of Parallel and Distributed Systems |
| SWORD Depositor: | MTMT Injector |
| Depositing User: | MTMT Injector |
| Date Deposited: | 06 Aug 2025 13:42 |
| Last Modified: | 06 Aug 2025 13:51 |
| URI: | https://eprints.sztaki.hu/id/eprint/10958 |
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