Vághy, Mihály András and Otero-Muras, I and Pájaro, M and Szederkényi, Gábor (2024) A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks. BULLETIN OF MATHEMATICAL BIOLOGY, 86 (2). ISSN 0092-8240 10.1007/s11538-023-01251-3

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Abstract

In this paper, a finite volume discretization scheme for partial integro-differential equations (PIDEs) describing the temporal evolution of protein distribution in gene regulatory networks is proposed. It is shown that the obtained set of ODEs can be formally represented as a compartmental kinetic system with a strongly connected reaction graph. This allows the application of the theory of nonnegative and compartmental systems for the qualitative analysis of the approximating dynamics. In this framework, it is straightforward to show the existence, uniqueness and stability of equilibria. Moreover, the computation of the stationary probability distribution can be traced back to the solution of linear equations. The discretization scheme is presented for one and multiple dimensional models separately. Illustrative computational examples show the precision of the approach, and good agreement with previous results in the literature.

Item Type:	Article
Subjects:	Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Divisions:	Systems and Control Lab
SWORD Depositor:	MTMT Injector
Depositing User:	MTMT Injector
Date Deposited:	24 Feb 2024 16:55
Last Modified:	24 Feb 2024 16:55
URI:	https://eprints.sztaki.hu/id/eprint/10707

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