Stability of biochemical reaction networks with general kinetics and distributed time delays

Molnár, Gyula and Vághy, Mihály András and Szederkényi, Gábor (2025) Stability of biochemical reaction networks with general kinetics and distributed time delays. JOURNAL OF MATHEMATICAL CHEMISTRY, 63. ISSN 0259-9791 10.1007/s10910-025-01756-3

[img] Text
MolnarGy_1_36397605_ny.pdf

Download (2MB)

Abstract

Distributed delays play an important role in biological modeling, and are often inevitable to obtain a sufficiently precise quantitative description of certain important processes. It is known from previous studies that mass-action type complex balanced chemical reaction networks (CRNs) containing distributed delays are stable. In this paper, we consider complex balanced biochemical reaction networks with distributed delays, containing a general class of reaction rates including Michaelis–Menten and Hill-type kinetics. We show that for integrable delay distributions defined on a finite time interval, there exists precisely one equilibrium in each stoichiometric compatibility class. The local stability of the equilibria is shown using a logarithmic Lyapunov–Krasovski functional. The theoretical results are demonstrated through two illustrative examples.

Item Type: Article
Subjects: Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Divisions: Systems and Control Lab
SWORD Depositor: MTMT Injector
Depositing User: MTMT Injector
Date Deposited: 17 Dec 2025 07:30
Last Modified: 17 Dec 2025 07:30
URI: https://eprints.sztaki.hu/id/eprint/11002

Update Item Update Item