Miklós, István and Heather, Smith (2015) Sampling and counting genome rearrangement scenarios. BMC BIOINFORMATICS, 16 (14). S6. ISSN 1471-2105 10.1186/1471-2105-16-S14-S6

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Abstract

Even for moderate size inputs, there are a tremendous number of optimal rearrangement scenarios, regardless what the model is and which specific question is to be answered. Therefore giving one optimal solution might be misleading and cannot be used for statistical inferring. Statistically well funded methods are necessary to sample uniformly from the solution space and then a small number of samples are sufficient for statistical inferring.

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