Szederkényi, Gábor and Kocsis, Dorottya and Vághy, Mihály András and Czárán, Domonkos Tamás and Sasvári, Péter and Lengyel, Miléna and Naszlady, Márton Bese and Kreis, F and Antal, István and Csépányi-Kömi, Roland and Erdő, Franciska (2024) Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease. PLOS ONE, 19 (4). ISSN 1932-6203 10.1371/journal.pone.0299501

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Abstract

Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,

Item Type:	Article
Uncontrolled Keywords:	ABSORPTION; DEXAMETHASONE; ARTICLE; MOUSE; PREDICTION; nonhuman; in vitro study; simulation; drug formulation; drug delivery system; indometacin; room temperature; CAFFEINE; diclofenac; mathematical model; piroxicam; drug penetration; cream; Product development; diffusion chamber; psoriasis; Epidermis; compartment model; skin penetration; dermis; skin on a chip;
Subjects:	Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Divisions:	Systems and Control Lab
SWORD Depositor:	MTMT Injector
Depositing User:	MTMT Injector
Date Deposited:	31 May 2024 08:16
Last Modified:	31 May 2024 08:16
URI:	https://eprints.sztaki.hu/id/eprint/10730

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