Juhász, Vencel and Ország, Anna and Balla, Dorottya and Szabó, Liliána and Sydó, Nóra and Kiss, Orsolya and Csulak, Emese and Babity, Máté and Dohy, Zsófia and Skoda, Réka and Becker, Dávid and Merkely, Béla Péter and Benczúr, András, ifj and Vágó, Hajnalka and Kerepesi, Csaba (2024) Blood Test-Based age Acceleration Is Inversely Associated with High-Volume Sports Activity. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 56 (5). pp. 868-875. ISSN 0195-9131 10.1249/MSS.0000000000003380

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Abstract

We develop blood test-based aging clocks and examine how these clocks reflect high-volume sports activity.We use blood tests and body metrics data of 421 Hungarian athletes and 283 age-matched controls (mean age 24.1 and 23.9 years, respectively), the latter selected from a group of healthy Caucasians of the National Health and Nutrition Examination Survey (NHANES) to represent the general population (n = 11,412). We train two age prediction models (i.e., aging clocks) using the NHANES dataset: the first model relies on blood test parameters only, while the second one additionally incorporates body measurements and sex.We find lower age acceleration among athletes compared to the age-matched controls with a median value of -1.7 and 1.4 years, p < 0.0001. BMI is positively associated with age acceleration among the age-matched controls (r = 0.17, p < 0.01) and the unrestricted NHANES population (r = 0.11, p < 0.001). We find no association between BMI and age acceleration within the athlete dataset. Instead, age acceleration is positively associated with body fat percentage (r = 0.21, p < 0.05) and negatively associated with skeletal muscle mass (Pearson r: -0.18, p < 0.05) among athletes. The most important blood test features in age predictions were serum ferritin, mean cell volume, blood urea nitrogen, and albumin levels.We develop and apply blood test-based aging clocks to adult athletes and healthy controls. The data suggest that high-volume sports activity is associated with slowed biological aging. Here, we propose an alternative, promising application of routine blood tests.

Item Type:	Article
Subjects:	Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Divisions:	Informatics Laboratory
SWORD Depositor:	MTMT Injector
Depositing User:	MTMT Injector
Date Deposited:	09 May 2024 07:12
Last Modified:	09 May 2024 07:12
URI:	https://eprints.sztaki.hu/id/eprint/10722

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