Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt (2024) Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness. AGING CELL, 23 (4). ISSN 1474-9718 10.1111/acel.14101

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Abstract

Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.

Item Type:	Article
Subjects:	Q Science > QA Mathematics and Computer Science > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Divisions:	Informatics Laboratory
SWORD Depositor:	MTMT Injector
Depositing User:	MTMT Injector
Date Deposited:	09 May 2024 07:09
Last Modified:	09 May 2024 07:09
URI:	https://eprints.sztaki.hu/id/eprint/10721

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